Nature Immunology is a multidisciplinary journal that publishes papers of the highest quality and significance in all areas of immunology. Priority is given to work that provides fundamental insight into the workings of the immune system. Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination; cellular and systemic immunity; vaccines; immune tolerance; autoimmunity and tumor immunology, microbial immunopathology; and transplantation.

Nature Immunology places its highest priority on fair and rapid review and speedy publication. Decisions on whether to send a manuscript out for peer review are normally made within two working days of receipt and decisions about publication are typically made within two days of receipt of the referees' reports.

In addition to publishing significant original research, Nature Immunology also publishes commentary, News and Views, brief research notes, historical perspectives, correspondence from readers and reviews of the literature, thus serving as the major conduit of top-quality information for the immunology community.