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Guidance on Allocating and Targeting Pandemic Influenza Vaccine (2008) by U.S. Department Of Health And Human Services U.S. Department Of Homeland Security
Publisher: U.S. Department Of Health And Human Services U.S. Department Of Homeland Security July 2008 | ASIN R20090503A | 26 Pages | PDF | 1.4 MB

Effective allocation of pandemic influenza vaccine will play a critical role in preventing influenza and reducing its effects on health and society when a pandemic arrives. The specific type of influenza that causes a pandemic will not be known until it occurs. Developing a new vaccine in response will take several months and pandemic vaccine may not be available when cases first occur in the United States. Moreover, once vaccine production begins, it will not be possible to make enough new vaccine to protect everyone in the early stages of a pandemic.

The U.S. Government is taking steps to minimize the need to make vaccine allocation decisions by supporting efforts to increase domestic influenza vaccine production capacity. Significant funding is being provided to develop new vaccine technologies that allow production of enough pandemic influenza vaccine for any person in the United States who wants to be vaccinated within six months of a pandemic declaration. Until this goal is met, Federal, State, local and tribal governments, communities, and the private sector will need guidance on who should be vaccinated earlier during the pandemic to best protect our people, communities, and country. Issues to consider in drafting guidance on pandemic influenza vaccination are different and more complex than in developing recommendations for annual vaccination against seasonal influenza. In contrast with seasonal influenza, during a pandemic nobody in the population is likely to have immunity to the virus, many more people will become ill, and rates of severe illness, complications and death are likely to be much higher and more widely distributed throughout the population. The greater frequency and severity of disease will increase the burden on health care providers and institutions and may disrupt critical products and services in health care and other sectors. National and homeland security could be threatened if illness among military and other critical personnel reduces their capabilities. Because the needs that must be addressed by pandemic vaccination differ from seasonal influenza vaccination, the guidance on vaccination differs as well. This guidance is intended to provide strong advice to support planning an effective and consistent pandemic response by States and communities. Nevertheless, it is important that plans are flexible as the guidance may be modified based on the status of vaccine technology, the characteristics of pandemic illness, and risk groups for severe disease – factors that will remain unknown until a pandemic actually occurs.

Contents
Cover
Introduction
How the Guidance was Developed
Draft Guidance on Allocating and Targeting Pandemic Influenza Vaccine
Goals and Objectives
General Principles and Guidance on Pandemic Vaccination
Framework for Targeting Pandemic Influenza Vaccine
Defining who is included in each target group
Guidance for Prioritizing Pandemic Vaccination
Vaccination Tier 1 at All Pandemic Severities
Potential sub-prioritization of Tier 1
Vaccination Tier 2 through 5 by Pandemic Severity
Guidance for severe pandemics (PSI 4 or 5)
Guidance for moderate pandemics (PSI 3)
Guidance for less severe pandemics (PSI 1 or 2)
Appendix A Additional Information on the Draft Guidance Development Process
Input from Stakeholders and the Public
Decision Analysis
Ethical Considerations
Vetting the draft guidance with the public and stakeholders
Appendix B Pandemic Severity Index
Appendix C Description and Rationale for Groups Targeted for Pandemic Vaccination




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