Toxicity Testing for Assessment of Environmental Agents: Interim Report: Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council
National Academies Press | ISBN: 0309100925 | 2006-04-07 | PDF (OCR) | 270 pages | 10.09 Mb
In the Uniled Stales, several federal agencies have been given authority to regulate a variety of environmental agents that might harm public health. Accordingly. the agencies implement regulations thai establish maximum acceptable concentrations of environmental agents in drinking waler, set permissible limits of exposure of workers, define labeling requiremenls. establish loleranees for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Toxicity testing in laboratory animals provides many of the data needed for risk assessment, such as information on the possible effects of exposure to a substance and the exposure concentrations at which effects might be observed.
New directives and initiatives for toxicity testing in the United States and Europe reflect an increased demand for loxicity information to provide a rational basis for regulating environmental agehiS. At the same time, new testing teehnologies and methods have continued to emerge. The U.S. Environmental Protection Agency (EPA} recognized the need for a comprehensive review of established and newly developed toxicity-testing methods and strategies and asked the National Research Council (NRC) lo conduct an independent review and to develop a long-range vision and strategy for toxicity testing. in response to EPA's request, the NRC convened Ihe Committee on Toxicity Testing and Assessment of Environmental Agents.
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